Notre Dame jumped out to a 15-6 lead to start the game.
As strange as this sounds, that might have been a bad thing. The Fighting Irish started relaxing and couldn't grab a rebound and Prattsburgh was getting all the boards and hitting a lot of shots and came away with a 70-64 win.
The Vikings won by six points, but the game was far from that close.
After the Irish opened the 9-point lead to start the game, star guard Kevin Francis got into foul trouble and sat for a good portion of the second quarter.
That was when Prattsburgh took over.
Notre Dame led 21-12 at the end of the first, but wound up trailing 34-27 at halftime.
Ryan Caron may have played the game of his life for the Vikings, with 29 points. He scored seven of those points in the second period as Prattsburgh dominated.
Patrick Wightman hit two 3-pointers and had another basket in the frame. Wightman finished with 21 points, including five 3-pointers.
It looked good for Notre Dame as Francis opened up the third quarter with a basket and-1.
But again, Prattsburgh took over with Garrett Parker scoring twice, Wightman dropping and 3-pointer and Caron adding a bucket to give the Vikings a 47-35 advantage.
Kevin Schildwaster hit two 3-pointers and another basket in the third quarter to keep the Fighting Irish within striking distance, but the third quarter ended with Prattsburgh leading 58-49.
That lead was expanded to 68-54 as Caron had two free throws, and three baskets in a quick stretch.
Notre Dame made a late charge with Vinny Zambito hitting a long 2-pointer and Nick Bochiccho draining a trey, but the game wound up being a blowout.
Garrett Parker scored eight of his points in the second half for Prattsburgh while Schildwaster added 13 points to Francis' 18 and Tommy Rapone scored eight points, all in the first half.
Prattsburgh (12-3) is currently ranked third in Class D2 in the Section 5 sectional bracket, while ND is 10-2 and the top ranked in D1.
With the NYSPHSAA looking force teams to drop two games in the season, means this might be the end of the great rivalry.
Notre Dame will only have three non-league games, and two of those will be in the Lions Club Tournament, leaving just one open slot.